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KMID : 1007020040020010009
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Korean Soceity of Osteroporosis
2004 Volume.2 No. 1 p.9 ~ p.16
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The Relationship between T869C Polymorphism of Transforming Growth Factor-β1(TGF-β1) Gene and Change in Bone Mass after Hormone Replacement Therapy in Postmenopausal Korean Women
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Kim Jung-Gu
Ku Seung-Yup
Kim Seok-Hyun
Choi Young-Min
Moon Shin-Yong
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Abstract
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Objectives: To investigate the relationship between the T869C polymorphism of transforming growth factor-β1(TGF-β1) gene, and change in bone mineral density(BMD) after hormone replacement therapy(HRT) in postmenopausal Korean women.
Methods: The T869C polymorphism of TGF-β1 gene was analyzed by allele specific polymerase chain reaction(PCR) and electrophoresis in 302 postmenopausal Korean women receiving sequential HRT for 1 year. Serum bone alkaline phosphatase(BAP), CrossLaps(CTX), and TGF-β1 were measured by immunoassay, and enzyme linked immunosorbent assay respectively. BMD at the lumbar spine and proximal femur was determined by dual energy X-ray absorptiometry.
Results: The TGF-β1 genotypes were not related with annual percent change of BMD at lumbar spine and proximal femur after HRT, and were not distributed differently between HRT-responders and HRT-nonresponders(women who lose more than 3% of bone mass per year). There were no associations between serum TGF levels or their 6 month percentage changes after HRT and basal BMD or annual changes in BMD after HRT. The change in serum TGF-β1 level did not correlate with change in serum levels of bone turnover markers after HRT.
Conclusion: The T869C polymorphism of TGF-β1 gene is not associated with change in BMD after HRT in postmenopausal Korean women,
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KEYWORD
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Postmenopausal women, TGF-β1, polymorphism, BMD, HRT
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